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Extract:
Aimed at improving cellular bioenergetics, counteracting oxidative stress and slowing down some age-related pathologies
Cardiovascular disease & CoQ10
(1) Cardiac surgery past clinical trials suggested improved postop cardiac function and reduced structural damage, recent RCT failed to demonstrate a difference in clinical outcomes
(2) CPR – CoQ10 with mild hypothermia after cardiac arrest/CPR recent RCT demonstrated higher 3-month survival rate (68% vs 29%) and higher rate of good neurological outcome (36% vs 20%)
(3) CHF recent RCT of patients with end-stage heart failure awaiting transplant, 60mg CoQ10 QD for 3 mos in addition to conventional therapy, showed improvement in dyspnea, NYHA class, nocturia, fatigue, and improved 6-min walk test (CoQ10 269 to 382m vs placebo 254 to 177m)…
Statins & CoQ10
Due to a common biosynthetic pathway of CoQ10 and cholesterol, statins adversely affect CoQ10 levels…
Mitochondrial myopathies & CoQ10
Different forms of mitochondrial myopathies respond to CoQ10 supplementation…
Parkinsons disease & CoQ10
Data suggesting impairment of mitochondrial function and oxidative damage in brain of pts with PD. CoQ10 has been shown to be neuroprotective against ischemia due to mitochondrial toxins…
Friedreichs ataxia & CoQ10
Trial of 10 pts treated with CoQ10 and vit E, followed for 4 yrs improvement in markers…
Migraine & CoQ10
RCT of 42 pts for migraine prophylaxis (CoQ10 100mg TID) demonstrated reduction in attack frequency…
Macular degeneration & CoQ10
RCT of 101 pts treated with acetyl-L-carnitine, n-3 fatty acids, and CoQ10 demonstrated improvement in visual field mean defect…
– Coenzyme Q10 is present throughout the human body. It aids metabolic reactions, such as the transformation of food into ATP, the energy used by the body. Cell mitochondria (the part of cells where energy is produced) show the greatest concentration of coenzyme Q10 in the body. Similarly, organs that contain higher … More information at Coenzyme Q10: CoQ10 BioEnergetic Synopsis.
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